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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PFKFB3
All Species:
31.21
Human Site:
Y353
Identified Species:
62.42
UniProt:
Q16875
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q16875
NP_001138915.1
520
59609
Y353
A
L
R
E
Q
D
K
Y
Y
Y
R
Y
P
T
G
Chimpanzee
Pan troglodytes
XP_001147864
523
59913
Y353
A
L
R
E
Q
D
K
Y
Y
Y
R
Y
P
T
G
Rhesus Macaque
Macaca mulatta
XP_001107535
520
59589
Y353
A
L
R
E
Q
D
K
Y
Y
Y
R
Y
P
T
G
Dog
Lupus familis
XP_544267
559
63551
Y366
A
L
R
E
Q
D
K
Y
Y
Y
R
Y
P
T
G
Cat
Felis silvestris
Mouse
Mus musculus
P70265
519
59907
Y359
A
L
R
D
Q
E
K
Y
L
Y
R
Y
P
G
G
Rat
Rattus norvegicus
O35552
555
63657
Y353
A
L
R
E
Q
D
K
Y
Y
Y
R
Y
P
T
G
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001516067
579
65588
Y419
A
L
R
D
Q
D
K
Y
Y
Y
R
Y
P
S
G
Chicken
Gallus gallus
Q91348
470
54386
A324
V
P
Y
E
Q
W
K
A
L
N
E
I
D
A
G
Frog
Xenopus laevis
NP_001088535
470
54750
A324
V
P
Y
E
Q
W
K
A
L
N
E
I
D
A
G
Zebra Danio
Brachydanio rerio
NP_998562
536
62010
Y356
S
L
R
D
Q
D
K
Y
Y
Y
R
Y
P
S
G
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q21122
457
52072
K311
A
Q
T
A
Q
H
L
K
P
D
F
H
T
E
Y
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
P32604
452
52576
G306
A
L
D
E
L
D
A
G
V
C
D
G
M
T
Y
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
96.7
99.6
84.6
N.A.
65.5
89.9
N.A.
76.6
61.1
65.5
72.3
N.A.
N.A.
N.A.
47.1
N.A.
Protein Similarity:
100
97.1
99.8
87.6
N.A.
77.8
91.7
N.A.
84.2
77.1
76.7
84.1
N.A.
N.A.
N.A.
62.8
N.A.
P-Site Identity:
100
100
100
100
N.A.
73.3
100
N.A.
86.6
26.6
26.6
80
N.A.
N.A.
N.A.
13.3
N.A.
P-Site Similarity:
100
100
100
100
N.A.
86.6
100
N.A.
100
26.6
26.6
100
N.A.
N.A.
N.A.
20
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
40.9
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
59.4
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
75
0
0
9
0
0
9
17
0
0
0
0
0
17
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
9
0
0
0
0
0
% C
% Asp:
0
0
9
25
0
67
0
0
0
9
9
0
17
0
0
% D
% Glu:
0
0
0
67
0
9
0
0
0
0
17
0
0
9
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
9
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
9
0
0
0
9
0
9
84
% G
% His:
0
0
0
0
0
9
0
0
0
0
0
9
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
17
0
0
0
% I
% Lys:
0
0
0
0
0
0
84
9
0
0
0
0
0
0
0
% K
% Leu:
0
75
0
0
9
0
9
0
25
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
9
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
17
0
0
0
0
0
% N
% Pro:
0
17
0
0
0
0
0
0
9
0
0
0
67
0
0
% P
% Gln:
0
9
0
0
92
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
67
0
0
0
0
0
0
0
67
0
0
0
0
% R
% Ser:
9
0
0
0
0
0
0
0
0
0
0
0
0
17
0
% S
% Thr:
0
0
9
0
0
0
0
0
0
0
0
0
9
50
0
% T
% Val:
17
0
0
0
0
0
0
0
9
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
17
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
17
0
0
0
0
67
59
67
0
67
0
0
17
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _